The Components of Life - download pdf or read online

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Anions such as bisulfite can deaminate (remove an amine from)cytosine to form uracil. This change can alter the genetic message by causing C-to-T transitions. Exposure to acid causes the loss of purine residues, though specific enzymes exist in cells to repair these lesions. Exposure to UV light can cause adjacent pyrimidines to dimerize, while oxidative damage from free radicals or strong oxidizing agents can cause a variety of lesions that are mutagenic if not repaired. Halogens such as chlorine and bromine react directly with uracil, adenine, and guanine, giving substituted bases that are often mutagenic.

Humans can synthesize 10 of them (by interconversions, or mutual conversions) from each other or from other molecules of intermediary metabolism, but the other 10 (essential amino acids: arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) must be consumed in the diet. buildiNg blocks of PRoteiNs Proteins are of primary importance to the continuing functioning of life on Earth. Proteins catalyze the vast Molecular Components: Amino Acids CHAPTER 2 7 The Components of Life 7 majority of chemical reactions that occur in the cell.

The 5'-triphosphate residue goes through a chemical process called esterification, forming a structure called a cap. At the 3' ends, eukaryotic mRNAs typically contain long runs of adenosine residues (polyA) that are not encoded in the DNA but are added enzymatically after transcription. Eukaryotic mRNA molecules are usually composed of small segments of the original gene and are generated by a process of cleavage and rejoining from an original precursor RNA 17 7 The Components of Life 7 (pre-mRNA) molecule, which is an exact copy of the gene.

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